ARG45803
anti-Deptor antibody
anti-Deptor antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Deptor |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Deptor |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human Deptor. |
| Conjugation | Un-conjugated |
| Alternate Names | DEPTOR; DEP domain containing MTOR-interacting protein; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; DEPDC6; DEP.6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 48 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q570Y9 Mouse DEP domain-containing mTOR-interacting protein Swiss-port # Q8TB45 Human DEP domain-containing mTOR-interacting protein |
|---|---|
| Gene Symbol | DEPTOR |
| Gene Full Name | DEP domain containing MTOR-interacting protein |
| Background | Enables phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Feb 2025] |
| Function | Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes. [UniProt] |
| Cellular Localization | Lysosome; Membrane. [UniProt] |
| Calculated MW | 46 kDa |
| PTM | Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2. [UniProt] |
Images (5) Click the Picture to Zoom In
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ARG45803 anti-Deptor antibody IHC-P image
Immunohistochemistry: Human lung cancer stained with ARG45803 anti-Deptor antibody at 2 μg/ml dilution.
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ARG45803 anti-Deptor antibody WB image
Western blot: MCF-7 stained with ARG45803 anti-Deptor antibody at 0.5 μg/ml dilution.
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ARG45803 anti-Deptor antibody FACS image
Flow Cytometry: MCF-7 stained with ARG45803 anti-Deptor antibody at 1 µg/10^6 cells dilution.
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ARG45803 anti-Deptor antibody WB image
Western blot: Rat heart stained with ARG45803 anti-Deptor antibody at 0.5 μg/ml dilution.
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ARG45803 anti-Deptor antibody WB image
Western blot: Mouse heart stained with ARG45803 anti-Deptor antibody at 0.5 μg/ml dilution.
