ARG58532

anti-Desmoglein 2 antibody

anti-Desmoglein 2 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes Desmoglein 2
Tested Reactivity Hu, Ms, Rat
Tested Application FACS, ICC/IF, IHC-P
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Desmoglein 2
Antigen Species Human
Immunogen Synthetic peptide derived from Human Desmoglein 2.
Conjugation Un-conjugated
Full Name desmoglein 2
Alternate Names ARVD10; Desmoglein-2; ARVC10; CMD1BB; CDHF5; Cadherin family member 5; HDGC

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:100
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 13511 Mouse DSG2

GeneID: 1829 Human DSG2

Swiss-port # O55111 Mouse Desmoglein-2

Swiss-port # Q14126 Human Desmoglein-2

Gene Symbol DSG2
Gene Full Name desmoglein 2
Background Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jul 2008]
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. [UniProt]
Calculated MW 122 kDa