anti-Drebrin antibody [DBN-N-03] (PE)

anti-Drebrin antibody [DBN-N-03] (PE) for Flow cytometry and Human

Cancer antibody; Neuroscience antibody; Signaling Transduction antibody


Product Description PE-conjugated Mouse Monoclonal antibody [DBN-N-03] recognizes Drebrin
Tested Reactivity Hu
Tested Application FACS
Specificity The clone DBN-N-03 recognizes drebrin, an approximately 100-125 kDa regulator of actin cytoskeleton.
Host Mouse
Clonality Monoclonal
Clone DBN-N-03
Isotype IgG2b
Target Name Drebrin
Antigen Species Human
Immunogen Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
Conjugation PE
Alternate Names Developmentally-regulated brain protein; D0S117E; Drebrin

Application Instructions

Application Suggestion
Tested Application Dilution
FACS4 µl / 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Note The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Buffer PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
Preservative 15 mM Sodium azide
Stabilizer 0.2% (w/v) high-grade protease free BSA
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 1627 Human DBN1

Swiss-port # Q16643 Human Drebrin

Gene Symbol DBN1
Gene Full Name drebrin 1
Background Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.
Function Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. [UniProt]
Research Area Cancer antibody; Neuroscience antibody; Signaling Transduction antibody
Calculated MW 71 kDa