ARG10566

anti-EBV LMP1 antibody [D24-G]

anti-EBV LMP1 antibody [D24-G] for IHC-Formalin-fixed paraffin-embedded sections and EBV

Overview

Product Description Rabbit Monoclonal antibody [D24-G] recognizes EBV LMP1
Tested Reactivity EBV
Tested Application IHC-P
Host Rabbit
Clonality Monoclonal
Clone D24-G
Isotype IgG
Target Name EBV LMP1
Antigen Species Virus
Immunogen Synthetic peptide around the internal region of EBV's Latent Membrane Protein-1
Conjugation Un-conjugated
Full Name LMP1

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA
Preservative 0.05% Sodium azide
Stabilizer 20 mg/ml BSA
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol LMP1
Gene Full Name LMP1
Function Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. [UniProt]

Images (1) Click the Picture to Zoom In

  • ARG10566 anti-EBV LMP1 antibody [D24-G] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded HRS cells of the classical Hodgkin Lymphoma (4 µm section) stained with ARG10566 anti-EBV LMP1 antibody [D24-G].