ARG45647
anti-ERAP2 antibody
anti-ERAP2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ERAP2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ERAP2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human ERAP2. |
| Conjugation | Un-conjugated |
| Alternate Names | ERAP2; Endoplasmic Reticulum Aminopeptidase 2; L-RAP; LRAP; Leukocyte-Derived Arginine Aminopeptidase; EC 3.4.11.-; EC 3.4.11.3 47; EC 3.4.11 47 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 110 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6P179 Human Endoplasmic reticulum aminopeptidase 2 |
|---|---|
| Gene Symbol | ERAP2 |
| Gene Full Name | Endoplasmic Reticulum Aminopeptidase 2 |
| Background | This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016] |
| Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. [UniProt] |
| Cellular Localization | Endoplasmic reticulum; Membrane. [UniProt] |
| Calculated MW | 110 kDa |
Images (3) Click the Picture to Zoom In
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ARG45647 anti-ERAP2 antibody IHC-P image
Immunohistochemistry: Human lung cancer stained with ARG45647 anti-ERAP2 antibody at 2 μg/ml dilution.
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ARG45647 anti-ERAP2 antibody WB image
Western blot: CACO-2 stained with ARG45647 anti-ERAP2 antibody at 0.5 μg/ml dilution.
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ARG45647 anti-ERAP2 antibody FACS image
Flow Cytometry: HL-60 stained with ARG45647 anti-ERAP2 antibody at 1 µg/10^6 cells dilution.
