ARG46790
anti-ERBB2 antibody
anti-ERBB2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Goat Polyclonal antibody recognizes ERBB2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Specificity | Detects endogenous levels of ERBB2 by Western blot. |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ERBB2 |
| Antigen Species | Human |
| Immunogen | Purified recombinant peptide derived from within residues 1,177 aa to the C-terminus of human ERBB2 produced in E. coli. |
| Conjugation | Un-conjugated |
| Alternate Names | NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Epitope affinity purified |
| Buffer | PBS, 0.05% Sodium azide and 20% Glycerol. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 20% Glycerol |
| Concentration | 3 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P04626 Human Receptor tyrosine-protein kinase erbB-2 Swiss-port # P70424 Mouse Receptor tyrosine-protein kinase erbB-2 |
|---|---|
| Gene Symbol | ERBB2 |
| Gene Full Name | Erb-B2 Receptor Tyrosine Kinase 2 |
| Background | c-erbB-2 is a 185kDa transmembrane tyrosine kinase belongs to the epidermal growth factor receptor (EGFR) family. This family comprises four homologous receptors ERFR, c-erbB-2, cerbB-3 and c-erbB-4. The HER-2 gene is located on chromosome 17 at q21. Activation of c-erbB-2 through autophosphorylation at tyrosine residues, is initiated by either homo- or heterodimerization and triggers intracellular signaling events, which are crucial for cell growth, differentiation and survival. This antibody labels activated c-cerbB-2 that is non-phosphorylated at tyrosine residue. |
| Cellular Localization | Membrane |
| Calculated MW | 185 kDa |
Images (7) Click the Picture to Zoom In
-
ARG46790 anti-ERBB2 antibody IHC-P image
Immunohistochemistry: Human appendix stained with ARG46790 anti-ERBB2 antibody at 1:500 dilution.
-
ARG46790 anti-ERBB2 antibody IHC-P image
Immunohistochemistry: Human breast carcinoma stained with ARG46790 anti-ERBB2 antibody at 1:500 dilution.
-
ARG46790 anti-ERBB2 antibody IHC-P image
Immunohistochemistry: Human placenta stained with ARG46790 anti-ERBB2 antibody at 1:500 dilution.
-
ARG46790 anti-ERBB2 antibody IHC-P image
Immunohistochemistry: Human skin stained with ARG46790 anti-ERBB2 antibody at 1:500 dilution.
-
ARG46790 anti-ERBB2 antibody WB image
Western blot: SKOV3 stained with ARG46790 anti-ERBB2 antibody at 1:2500 dilution.
-
ARG46790 anti-ERBB2 antibody IHC-P image
Immunohistochemistry: Rat eye stained with ARG46790 anti-ERBB2 antibody at 1:500 dilution.
-
ARG46790 anti-ERBB2 antibody IHC-P image
Immunohistochemistry: Mouse liver stained with ARG46790 anti-ERBB2 antibody at 1:500 dilution.
