anti-ERBB3 / HER3 antibody

anti-ERBB3 / HER3 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human

Cancer antibody; Controls and Markers antibody; Signaling Transduction antibody
publication_link Publication1


Product Description Rabbit Polyclonal antibody recognizes ERBB3 / HER3
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name ERBB3 / HER3
Antigen Species Human
Immunogen Synthetic peptide derived from internal region of human c-erbB-3 protein.
Conjugation Un-conjugated
Alternate Names MDA-BF-1; LCCS2; p180-ErbB3; Proto-oncogene-like protein c-ErbB-3; c-erbB3; p85-sErbB3; Tyrosine kinase-type cell surface receptor HER3; p45-sErbB3; erbB3-S; HER3; c-erbB-3; ErbB-3; EC; Receptor tyrosine-protein kinase erbB-3

Application Instructions

Application Suggestion
Tested Application Dilution
Application Note IHC-P: Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Incubation Time: 30 min at RT.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Breast Carcinoma, Colon Carcinoma


Form Liquid
Purification Immunogen affinity purified
Buffer PBS (pH 7.6), 1% BSA and < 0.1% Sodium azide
Preservative < 0.1% Sodium azide
Stabilizer 1% BSA
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 2065 Human ERBB3

Swiss-port # P21860 Human Receptor tyrosine-protein kinase erbB-3

Background The gene for c-erbB-3/HER-3 is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6.2kb mRNA which is translated into a 160/180kDa glycoprotein. The c-erbB-3/HER-3 gene encodes secreted as well as transmembrane receptor tyrosine kinase due to alternative splicing. The c-erbB-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon.
Cellular Localization Membrane
Research Area Cancer antibody; Controls and Markers antibody; Signaling Transduction antibody
Calculated MW 148 kDa
PTM Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).

Images (1) Click the Picture to Zoom In

  • ARG52855 anti-ERBB3 / HER3 antibody IHC-P image

    Immunohistochemistry: Human Colon Carcinoma stained with ARG52855 anti-ERBB3 / HER3 antibody.

Specific References

HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition.

IHC-P / Human

Jia Xiaojing et al.
Molecular Medicine Reports.,  (2020)