ARG67248
anti-Estrogen receptor beta antibody [SQab30366]
anti-Estrogen receptor beta antibody [SQab30366] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Monoclonal antibody [SQab30366] recognizes Estrogen receptor beta. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30366 |
| Isotype | IgG |
| Target Name | Estrogen receptor beta |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to Human Estrogen receptor beta. |
| Conjugation | Un-conjugated |
| Alternate Names | ESR2; Estrogen Receptor 2; ER-Beta; NR3A2; Nuclear Receptor Subfamily 3 Group A Member 2; Estrogen Receptor Beta; Erb; Oestrogen Receptor Beta; ESTRB; Estrogen Receptor 2 (ER Beta); Estrogen Receptor Beta 2; Estrogen Receptor Beta 4; ESR-BETA; ER Beta; ESRB; ODG8 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ESR2 |
| Gene Full Name | Estrogen Receptor 2 |
| Background | This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008] |
| Function | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. [Uniprot] |
| Cellular Localization | Nucleus. [Uniprot] |
| Calculated MW | 59 kDa |
| PTM | Phosphoprotein. [Uniprot] |
Images (1) Click the Picture to Zoom In
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ARG67248 anti-Estrogen receptor beta antibody [SQab30366] IHC-P image
Immunohistochemistry: Human Breast stained with ARG67248 anti-Estrogen receptor beta antibody [SQab30366] at 1:100 dilution.
