ARG22263

anti-FKBP51 antibody [Hi51B]

anti-FKBP51 antibody [Hi51B] for Western blot,ICC/IF and Dog,Human,Mouse,Rat,Hamster,Rabbit

Overview

Product Description Mouse Monoclonal antibody [Hi51B] recognizes FKBP51
Tested Reactivity Hu, Ms, Rat, Dog, Hm, Rb
Tested Application ICC/IF, WB
Specificity Detects ~51kDa.
Host Mouse
Clonality Monoclonal
Clone Hi51B
Isotype IgG
Target Name FKBP51
Antigen Species Human
Immunogen Synthetic peptide from Human FKBP51
Conjugation Un-conjugated
Alternate Names HSP90-binding immunophilin; p54; FKBP-51; PPIase FKBP5; FK506-binding protein 5; Ptg-10; Rotamase; FKBP51; FKBP-5; FKBP54; 51 kDa FKBP; 51 kDa FK506-binding protein; EC 5.2.1.8; PPIase; Androgen-regulated protein 6; P54; AIG6; FF1 antigen; Peptidyl-prolyl cis-trans isomerase FKBP5; 54 kDa progesterone receptor-associated immunophilin

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:1000
WB1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein G.
Buffer PBS, 0.09% Sodium azide and 50% Glycerol
Preservative 0.09% Sodium azide
Stabilizer 50% Glycerol
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 14229 Mouse FKBP5

GeneID: 2289 Human FKBP5

Swiss-port # Q13451 Human Peptidyl-prolyl cis-trans isomerase FKBP5

Swiss-port # Q64378 Mouse Peptidyl-prolyl cis-trans isomerase FKBP5

Gene Symbol FKBP5
Gene Full Name FK506 binding protein 5
Background The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Function Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. [UniProt]
Cellular Localization Cytoplasm, Nucleus
Calculated MW 51 kDa

Images (2) Click the Picture to Zoom In

  • ARG22263 anti-FKBP51 antibody [Hi51B] ICC/IF image

    Immunocytochemistry: Mouse MK cells stained with ARG22263 anti-FKBP51 antibody [Hi51B] (red).

  • ARG22263 anti-FKBP51 antibody [Hi51B] WB image

    Western blot: Human HeLa cell lysates stained with ARG22263 anti-FKBP51 antibody [Hi51B] at 1:1000 dilution.