Overview

Product Description	Rabbit Polyclonal antibody recognizes FYB
Tested Reactivity	Hu, Ms
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	FYB
Antigen Species	Human
Immunogen	A 20 amino acid synthetic peptide within aa. 640 - 690 of human FYB.
Conjugation	Un-conjugated
Alternate Names	FYB; FYN-binding protein; FYN-T-binding protein; ADAP; FYB-120/130; SLAP130; SLP-76-associated phosphoprotein; SLAP-130; p120/p130; Adhesion and degranulation promoting adaptor protein; PRO0823

Application Instructions

Application Suggestion	Tested Application Dilution WB Assay-dependent
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Purification	Affinity chromatography purified
Buffer	PBS and 0.02% Sodium azide.
Preservative	0.02% Sodium azide
Concentration	1 mg/ml
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 23880 Mouse FYB GeneID: 2533 Human FYB Swiss-port # O15117 Human FYN-binding protein Swiss-port # O35601 Mouse FYN-binding protein
Gene Symbol	FYB
Gene Full Name	FYN binding protein
Background	Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells.Modulates the expression of interleukin-2 (IL-2).Involved in platelet activation.Prevents the degradation of SKAP1 and SKAP2.May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.
Function	Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. [UniProt]
Cellular Localization	Cytoplasm. Nucleus
Calculated MW	85 kDa
PTM	T-cell receptor ligation leads to increased tyrosine phosphorylation.

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