anti-Fibrillin 1 antibody

anti-Fibrillin 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse

publication_link Publication1


Product Description Rabbit Polyclonal antibody recognizes Fibrillin 1
Tested Reactivity Hu, Ms
Predict Reactivity Rat
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Fibrillin 1
Antigen Species Human
Immunogen Synthetic peptide between aa. 2780-2860 of Human Fibrillin 1.
Conjugation Un-conjugated
Alternate Names ECTOL1; MFS1; WMS; SGS; SSKS; MASS; GPHYSD2; WMS2; ACMICD; OCTD; Fibrillin-1; FBN

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100 - 1:300
Application Note IHC-P: Antigen Retrieval: Incubated in Tris-EDTA buffer (pH 8.0) with high-pressure and temperature.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol and 0.5% BSA
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 2200 Human FBN1

Swiss-port # P35555 Human Fibrillin-1

Gene Symbol FBN1
Gene Full Name fibrillin 1
Background This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome. [provided by RefSeq, Jul 2008]
Function Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. [UniProt]
Cellular Localization Secreted. Note=Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin (PubMed:24982166). Asprosin: Secreted. Note=Secreted into the plasma. Fibrillin-1: Secreted, extracellular space, extracellular matrix. [UniProt]
Calculated MW 312 kDa
PTM Fibrillin-1: Cleavage of N- and C-terminus by furin is required for incorporation into the extracellular matrix and assembly into microfibrils (PubMed:27026396). The C-terminus, which corresponds to the Asprosin chain, was initially thought to constitute a propeptide (PubMed:24982166). Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin, an essential step for incorporation of Fibrillin-1 into the nascent microfibrils (PubMed:24982166).

Fibrillin-1: Forms intermolecular disulfide bonds either with other fibrillin-1 molecules or with other components of the microfibrils. [UniProt]

Images (2) Click the Picture to Zoom In

  • ARG66654 anti-Fibrillin 1 antibody WB image

    Western blot: Mouse liver lysate stained with ARG66654 anti-Fibrillin 1 antibody.

  • ARG66654 anti-Fibrillin 1 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human breast carcinoma tissue stained with ARG66654 anti-Fibrillin 1 antibody. The picture on the right is blocked with the synthetic peptide.

Specific References

FBXO2 Promotes Proliferation of Endometrial Cancer by Ubiquitin-Mediated Degradation of FBN1 in the Regulation of the Cell Cycle and the Autophagy Pathway

IHC-P / Human

Xiaoxia Che et al.
Front Cell Dev Biol.,  (2020)