anti-GABAA Receptor gamma 2 antibody

anti-GABAA Receptor gamma 2 antibody for IHC-Frozen sections,Western blot and Mouse,Rat

Neuroscience antibody


Product Description Rabbit Polyclonal antibody recognizes GABAA Receptor gamma 2
Tested Reactivity Ms, Rat
Predict Reactivity Hu, Bov, Chk, Dog, NHuPrm
Tested Application IHC-Fr, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name GABAA Receptor gamma 2
Antigen Species Rat
Immunogen Fusion protein from the cytoplasmic loop of the gamma 2 subunit
Conjugation Un-conjugated
Alternate Names A; CAE2; ECA2; GEFSP3; Gamma-aminobutyric acid receptor subunit gamma-2; GABA

Application Instructions

Application Suggestion
Tested Application Dilution
Application Note Specific for the ~46k γ2-subunit of the GABAA receptor in Western blots.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Affinity purified.
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 50% Glycerol and 0.1 mg/ml BSA.
Stabilizer 50% Glycerol and 0.1 mg/ml BSA
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 14406 Mouse GABRG2

GeneID: 29709 Rat GABRG2

Swiss-port # P18508 Rat Gamma-aminobutyric acid receptor subunit gamma-2

Swiss-port # P22723 Mouse Gamma-aminobutyric acid receptor subunit gamma-2

Gene Symbol GABRG2
Gene Full Name gamma-aminobutyric acid (GABA) A receptor, gamma 2
Background Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α- subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).
Research Area Neuroscience antibody
Calculated MW 54 kDa
PTM Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability.

Images (1) Click the Picture to Zoom In

  • ARG52302 anti-GABAA Receptor gamma 2 antibody WB image

    Western Blot: 10 μg of rat hippocampal lysate showing specific immunolabeling of the ~46k gamma 2-subunit of the GABAA-R stained with GABAA Receptor gamma 2 antibody (ARG52302).