ARG46178
anti-GEMC1 antibody
anti-GEMC1 antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GEMC1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GEMC1 |
| Antigen Species | Human |
| Immunogen | A 19 amino acid synthetic peptide within aa. 130 - 180 of human GEMC1. |
| Conjugation | Un-conjugated |
| Alternate Names | GEMC1; GEMC1; GEMC1; Geminin coiled-coil domain-containing protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -228°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # A6NCL1 Human Geminin coiled-coil domain-containing protein 1 Swiss-port # Q3URY2 Mouse Geminin coiled-coil domain-containing protein 1 |
|---|---|
| Gene Symbol | GEMC1 |
| Gene Full Name | geminin coiled-coil domain-containing protein 1 |
| Background | Predicted to enable chromatin binding activity. Predicted to be involved in negative regulation of cell cycle and regulation of DNA-templated DNA replication initiation. Predicted to act upstream of or within several processes, including cerebrospinal fluid circulation; multi-ciliated epithelial cell differentiation; and seminiferous tubule development. Predicted to be located in extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] |
| Function | Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity). [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 38 kDa |
| PTM | Phosphoprotein. [UniProt] |
