anti-GRM7 phospho (Ser862) antibody
anti-GRM7 phospho (Ser862) antibody for Western blot and Mouse,Rat
|Product Description||Rabbit Polyclonal antibody recognizes GRM7 phospho (Ser862)|
|Tested Reactivity||Ms, Rat|
|Predict Reactivity||Hu, Bov, Dog, NHuPrm, Zfsh|
|Immunogen||Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser862 conjugated to KLH|
|Alternate Names||MGLU7; GPRC1G; Metabotropic glutamate receptor 7; GLUR7; mGluR7; PPP1R87; MGLUR7|
|Application Note||Specific for the ~102k mGluR7 protein phosphorylated at Ser862. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|Buffer||10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol|
|Stabilizer||0.1 mg/ml BSA, 50% Glycerol|
|Storage Instruction||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Gene Full Name||glutamate receptor, metabotropic 7|
|Background||Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008).|
|Research Area||Neuroscience antibody|
|Calculated MW||102 kDa|
Images (1) Click the Picture to Zoom In
ARG52340 anti-GRM7 phospho (Ser862) antibody WB image
Western blot: Mouse brain lysate showing the specific immunolabeling of the ~102k mGluR7 protein phosphorylated at Ser 862 stained with ARG52340 anti-GRM7 phospho (Ser862) antibody. Immunolabeling is blocked by the phospho-peptide used as antigen.