anti-GluR2 subunit phospho (Ser880) antibody

anti-GluR2 subunit phospho (Ser880) antibody for Western blot and Rat

Neuroscience antibody


Product Description Rabbit Polyclonal antibody recognizes GluR2 subunit phospho (Ser880)
Tested Reactivity Rat
Predict Reactivity Hu, Ms, NHuPrm, Zfsh
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name GluR2 subunit
Antigen Species Rat
Immunogen Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser880 conjugated to KLH
Conjugation Un-conjugated
Alternate Names AMPA-selective glutamate receptor 2; GluA2; GluR-K2; Glutamate receptor ionotropic, AMPA 2; GluR-2; HBGR2; GLUR2; GluR-B; Glutamate receptor 2; GLURB

Application Instructions

Application Suggestion
Tested Application Dilution
Application Note Specific for the ~100k GluR2 protein phosphorylated at Ser880.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Affinity Purified
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
Stabilizer 0.1 mg/ml BSA, 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 29627 Rat GRIA2

Swiss-port # P19491 Rat Glutamate receptor 2

Gene Symbol GRIA2
Gene Full Name glutamate receptor, ionotropic, AMPA 2
Background The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994). The number of GluR2 subunits in the AMPA receptor complex affects the Ca2+ permeability, rectification and single-channel conductance of AMPA receptors. Ser880 has been identified as the PKC phosphorylation site within the C-terminal region of GluR2 and has been shown to differentially regulate the interaction of the PDZ domain-containing proteins GRIP1 and PICK 1 (Matsuda et al., 1999)
Research Area Neuroscience antibody
Calculated MW 99 kDa
PTM Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).

Images (1) Click the Picture to Zoom In

  • ARG52319 anti-GluR2 subunit phospho (Ser880) antibody WB image

    Western blot: Rat brain homogenate showing specific immunolabeling of the ~100 kDa GluR2 protein phosphorylated at Ser880 (control) stained with ARG52319 anti-GluR2 subunit phospho (Ser880) antibody. Immunolabeling is blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown).