ARG67262
anti-Glutamine synthetase antibody [SQab30378]
anti-Glutamine synthetase antibody [SQab30378] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Monoclonal antibody [SQab30378] recognizes Glutamine synthetase. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30378 |
| Isotype | IgG |
| Target Name | Glutamine synthetase |
| Immunogen | Synthetic peptide. |
| Conjugation | Un-conjugated |
| Alternate Names | GLUL; Glutamate-Ammonia Ligase; Glutamine Synthetase ; GLNS; Palmitoyltransferase GLUL; EC 6.3.1.2; GS; Glutamate-Ammonia Ligase (Glutamine Synthase); Cell Proliferation-Inducing Protein 59; Proliferation-Inducing Protein 43; Glutamate--Ammonia Ligase; Glutamate Decarboxylase; Glutamine Synthase; EC 2.3.1.225; DEE116; PIG43; PIG59 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GLUL |
| Gene Full Name | Glutamate-Ammonia Ligase |
| Background | The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| Function | Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2. [Uniprot] |
| Cellular Localization | Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Microsome, Mitochondrion. [Uniprot] |
| Calculated MW | 42 kDa |
| PTM | Acetylation, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation. [Uniprot] |
Images (1) Click the Picture to Zoom In
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ARG67262 anti-Glutamine synthetase antibody [SQab30378] IHC-P image
Immunohistochemistry: Human Liver stained with ARG67262 anti-Glutamine synthetase antibody [SQab30378] at 1:100 dilution.
