ARG45468
anti-HERPUD1 antibody
anti-HERPUD1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes HERPUD1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | HERPUD1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human HERPUD1. |
| Conjugation | Un-conjugated |
| Alternate Names | HERPUD1; Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1; HERP; KIAA0025; Mif1; SUP; Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible, Ubiquitin-Like Domain Member 1; Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1 Protein; Methyl Methanesulfonate (MMF)-Inducible Fragment Protein 1; Homocysteine-Inducible Endoplasmic Reticulum Stress-Inducible Ubiquitin-Like Domain Member 1 Protein; MMS-Inducible; MIF1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 56 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q15011 Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like doma Swiss-port # Q9JJK5 Mouse Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like doma |
|---|---|
| Gene Symbol | HERPUD1 |
| Gene Full Name | Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1 |
| Background | The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013] |
| Function | Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. [UniProt] |
| Cellular Localization | Endoplasmic reticulum; Membrane. [UniProt] |
| Calculated MW | 44 kDa |
| PTM | Acetylation; Phosphoprotein. [UniProt] |
Images (5) Click the Picture to Zoom In
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ARG45468 anti-HERPUD1 antibody IHC-P image
Immunohistochemistry: Human breast cancer stained with ARG45468 anti-HERPUD1 antibody at 2 μg/ml dilution.
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ARG45468 anti-HERPUD1 antibody ICC/IF image
Immunofluorescence: A549 stained with ARG45468 anti-HERPUD1 antibody at 5 μg/ml dilution.
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ARG45468 anti-HERPUD1 antibody WB image
Western blot: PC-3 stained with ARG45468 anti-HERPUD1 antibody at 0.5 μg/ml dilution.
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ARG45468 anti-HERPUD1 antibody WB image
Western blot: Rat liver stained with ARG45468 anti-HERPUD1 antibody at 0.5 μg/ml dilution.
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ARG45468 anti-HERPUD1 antibody WB image
Western blot: Mouse liver stained with ARG45468 anti-HERPUD1 antibody at 0.5 μg/ml dilution.
