ARG67340
anti-HNF1 beta / Vhnf1 antibody [3B03]
anti-HNF1 beta / Vhnf1 antibody [3B03] for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF,Flow cytometry and Human,Rat
Overview
| Product Description | Mouse Monoclonal antibody [3B03] recognizes HNF1 beta / Vhnf1 |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 3B03 |
| Isotype | IgG2a |
| Target Name | HNF1 beta / Vhnf1 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein of human HNF1 beta / Vhnf1 expressed in E. Coli |
| Conjugation | Un-conjugated |
| Alternate Names | TCF-1; TCF1; Hepatocyte nuclear factor 1-alpha; HNF-1-alpha; HNF-1A; Liver-specific transcription factor LF-B1; MODY3; IDDM20; LFB1; HNF1; Transcription factor 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 70 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G |
| Purification Note | PBS, 0.01% Sodium azide and 30% Glycerol |
| Purity | 0.01% Sodium azide |
| Buffer | 30% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HNF1B |
| Gene Full Name | HNF1 homeobox A |
| Background | The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] |
| Function | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 61 kDa |
