ARG47094
anti-HPS4 antibody
anti-HPS4 antibody for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes HPS4 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | HPS4 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human HPS4. |
| Conjugation | Un-conjugated |
| Alternate Names | HPS4; BLOC-3 complex member HPS4; KIAA1667; Hermansky-Pudlak syndrome 4 protein; Light-ear protein homolog |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A |
| Buffer | PBS, 0.09% Sodium azide, 50% Glycerol and 0.5% BSA |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9NQG7 Human Hermansky-Pudlak syndrome 4 protein |
|---|---|
| Gene Symbol | HPS4 |
| Gene Full Name | HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 |
| Background | This gene encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in this gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| Function | Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. [UniProt] |
| Calculated MW | 77 kDa |
| PTM | Phosphoprotein. [UniProt] |
