anti-IL17 / IL17A antibody [TC11-18H10] (low endotoxin)

anti-IL17 / IL17A antibody [TC11-18H10] (low endotoxin) for ELISA,ELISPOT,Flow cytometry,Neutralizing and Mouse


Product Description Azide free and low endotoxin Rat Monoclonal antibody [TC11-18H10 ] recognizes IL17 / IL17A
Tested Reactivity Ms
Tested Application ELISA, ELISPOT, FACS, Neut
Specificity Mouse IL-17A.
Host Rat
Clonality Monoclonal
Clone TC11-18H10
Isotype IgG1, kappa
Target Name IL17 / IL17A
Antigen Species Mouse
Immunogen E. coli-expressed mouse IL-17
Conjugation Un-conjugated
Alternate Names IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8

Application Instructions

Application Suggestion
Tested Application Dilution
ELISA< 2 µg/ml
Application Note Neutralizing: The clone has been used to neutralize/block IL17 activity and it led to suppress IL1 alpha, IL1 beta, IL6 and IFN gamma releasing in CHS mouse model. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Note Low endotoxin
Buffer PBS
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 16171 Mouse IL17A

Swiss-port # Q62386 Mouse Interleukin-17A

Gene Symbol IL17A
Gene Full Name interleukin 17A
Background The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Function Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt]
Highlight Related products:
IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Anti-Rat IgG secondary antibodies;
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Calculated MW 18 kDa
PTM Found both in glycosylated and nonglycosylated forms.