ARG46204
anti-IL22RA1 antibody
anti-IL22RA1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IL22RA1 |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IL22RA1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide near the amino terminus of humanIL22RA1. |
| Conjugation | Un-conjugated |
| Alternate Names | IL22RA1; interleukin 22 receptor, alpha 1; IL-22 Receptor; IL22R; CRF2-9; IL22R1; IL22R; Interleukin-22 receptor subunit alpha-1; Cytokine receptor class-II member 9; IL-22 receptor subunit alpha-1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 65 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -254°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8N6P7 Human Interleukin-22 receptor subunit alpha-1 |
|---|---|
| Gene Symbol | IL22RA1 |
| Gene Full Name | interleukin 22 receptor, alpha 1 |
| Background | The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008] |
| Function | Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. [UniProt] |
| Cellular Localization | Cell membrane. [UniProt] |
| Calculated MW | 63 kDa |
| PTM | Phosphoprotein; Ubl conjugation; Disulfide bond; Glycoprotein. [UniProt] |
