ARG45788
anti-IRF2BP1 antibody
anti-IRF2BP1 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IRF2BP1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IRF2BP1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human IRF2BP1. |
| Conjugation | Un-conjugated |
| Alternate Names | IRF2BP1; Interferon Regulatory Factor 2 Binding Protein 1; IRF-2BP1; Probable RING-Type E3 Ubiquitin Transferase IRF2BP1; Interferon Regulatory Factor 2-Binding Protein 1; Probable E3 Ubiquitin-Protein Ligase IRF2BP1; IRF-2-Binding Protein 1; DKFZP434M154; EC 2.3.2.27 |
Application Instructions
| Application Suggestion |
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||
| Observed Size | 72 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8IU81 Human Interferon regulatory factor 2-binding protein 1 Swiss-port # Q8R3Y8 Mouse Interferon regulatory factor 2-binding protein 1 |
|---|---|
| Gene Symbol | IRF2BP1 |
| Gene Full Name | Interferon Regulatory Factor 2 Binding Protein 1 |
| Background | Enables transcription corepressor activity and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Feb 2025] |
| Function | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 62 kDa |
| PTM | Isopeptide bond; Methylation; Phosphoprotein; Ubl conjugation. [UniProt] |
Images (9) Click the Picture to Zoom In
-
ARG45788 anti-IRF2BP1 antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG45788 anti-IRF2BP1 antibody at 2 μg/ml dilution.
-
ARG45788 anti-IRF2BP1 antibody ICC/IF image
Immunofluorescence: TPC1 stained with ARG45788 anti-IRF2BP1 antibody at 5 μg/ml dilution.
-
ARG45788 anti-IRF2BP1 antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG45788 anti-IRF2BP1 antibody at 2 μg/ml dilution.
-
ARG45788 anti-IRF2BP1 antibody WB image
Western blot: 293T stained with ARG45788 anti-IRF2BP1 antibody at 0.5 μg/ml dilution.
-
ARG45788 anti-IRF2BP1 antibody IP image
Immunoprecipitation: HepG2 lysate immunoprecipitated with 2 μg ARG45788 anti-IRF2BP1 antibody.
-
ARG45788 anti-IRF2BP1 antibody FACS image
Flow Cytometry: HEL stained with ARG45788 anti-IRF2BP1 antibody at 1 µg/10^6 cells dilution.
-
ARG45788 anti-IRF2BP1 antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG45788 anti-IRF2BP1 antibody at 2 μg/ml dilution.
-
ARG45788 anti-IRF2BP1 antibody WB image
Western blot: Rat brain stained with ARG45788 anti-IRF2BP1 antibody at 0.5 μg/ml dilution.
-
ARG45788 anti-IRF2BP1 antibody WB image
Western blot: Mouse brain stained with ARG45788 anti-IRF2BP1 antibody at 0.5 μg/ml dilution.
