ARG46219
anti-IRGM antibody
anti-IRGM antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IRGM |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IRGM |
| Antigen Species | Human |
| Immunogen | A 17 amino acid synthetic peptide within aa. 30 - 80 of human IRGM. |
| Conjugation | Un-conjugated |
| Alternate Names | immunity-related GTPase family, M; IRGM; IFI1; IRGM1; LRG47; LRG-47; IFI1; Immunity-related GTPase family M protein; Immunity-related GTPase family M protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 20 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -269°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # A1A4Y4 Human Immunity-related GTPase family M protein Swiss-port # Q6AYC2 Rat Immunity-related GTPase family M protein |
|---|---|
| Gene Symbol | IRGM |
| Gene Full Name | immunity-related GTPase family, M |
| Background | This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016] |
| Function | Immunity-related GTPase that plays important roles in innate immunity and inflammatory response. [UniProt] |
| Cellular Localization | Cytoplasm; Cell membrane ; Endosome; Lysosome membrane; Cell projection; Cytoplasmic vesicle; Golgi apparatus. [UniProt] |
| Calculated MW | 20 kDa |
| PTM | Ubl conjugation. [UniProt] |
