ARG46220
anti-IZUMO1 antibody
anti-IZUMO1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IZUMO1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IZUMO1 |
| Antigen Species | Human |
| Immunogen | A 18 amino acid synthetic peptide within aa. 170 - 220 of human IZUMO1. |
| Conjugation | Un-conjugated |
| Alternate Names | IZUMO1; Izumo sperm-egg fusion 1; IZUMO; Izumo sperm-egg fusion protein 1; Oocyte binding/fusion factor; OBF; Sperm-specific protein izumo |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 52 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -270°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IZUMO1 |
| Gene Full Name | izumo sperm-egg fusion 1 |
| Background | The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008] |
| Function | Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization. [UniProt] |
| Cellular Localization | Cytoplasm; Cell membrane ; Cytoplasmic vesicle. [UniProt] |
| Calculated MW | 35, 39, 42 kDa |
| PTM | Phosphoprotein; Disulfide bond; Glycoprotein. [UniProt] |
