ARG47113
anti-Intersectin-2 antibody
anti-Intersectin-2 antibody for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes Intersectin-2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | Intersectin-2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human Intersectin-2. |
| Conjugation | Un-conjugated |
| Alternate Names | ITSN2; Intersectin-2; KIAA1256; SH3D1B; SWAP; SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A |
| Buffer | PBS, 0.09% Sodium azide, 50% Glycerol and 0.5% BSA |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ITSN2 |
| Gene Full Name | intersectin 2 |
| Background | This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017] |
| Function | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. [UniProt] |
| Cellular Localization | Cytoplasm. [UniProt] |
| Calculated MW | 193 kDa |
| PTM | Phosphoprotein. [UniProt] |
