ARG47115
anti-KATNIP antibody
anti-KATNIP antibody for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes KATNIP |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | KATNIP |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human KATNIP. |
| Conjugation | Un-conjugated |
| Alternate Names | KATNIP; Katanin-interacting protein; KIAA0556 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A |
| Buffer | PBS, 0.09% Sodium azide, 50% Glycerol and 0.5% BSA |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KATNIP |
| Gene Full Name | katanin interacting protein |
| Background | This gene encodes a novel, evolutionarily conserved, ciliary protein. In human hTERT-RPE1 cells, the protein is found at the base of cilia, decorating the ciliary axoneme, and enriched at the ciliary tip. The protein binds to microtubules in vitro and regulates their stability when it is overexpressed. A null mutation in this gene has been associated with Joubert syndrome, a recessive disorder that is characterized by a distinctive mid-hindbrain and cerebellar malformation and is also often associated with wider ciliopathy symptoms. Consistently, in a serum-starvation ciliogenesis assay, human fibroblast cells derived from patients with the mutation display a reduced number of ciliated cells with abnormally long cilia. [provided by RefSeq, Feb 2016] |
| Function | May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. [UniProt] |
| Cellular Localization | Cytoplasm; Cytoskeleton. [UniProt] |
| Calculated MW | 181 kDa |
| PTM | Phosphoprotein. [UniProt] |
