ARG45617
anti-KCNQ2 antibody
anti-KCNQ2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KCNQ2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KCNQ2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human KCNQ2. |
| Conjugation | Un-conjugated |
| Alternate Names | KCNQ2; Potassium Voltage-Gated Channel Subfamily Q Member 2; KCNA11; Kv7.2; HNSPC; ENB1; BFNC; Potassium Channel, Voltage Gated KQT-Like Subfamily Q, Member 2; Neuroblastoma-Specific Potassium Channel Subunit Alpha KvLQT2; Potassium Voltage-Gated Channel Subfamily KQT Member 2; Voltage-Gated Potassium Channel Subunit Kv7.2; EBN1; EBN; Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2; KQT-Like 2; DEE7 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 97 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KCNQ2 |
| Gene Full Name | Potassium Voltage-Gated Channel Subfamily Q Member 2 |
| Background | The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability. [UniProt] |
| Cellular Localization | Cell membrane. [UniProt] |
| Calculated MW | 96 kDa |
| PTM | Phosphoprotein; Ubl conjugation. [UniProt] |
Images (5) Click the Picture to Zoom In
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ARG45617 anti-KCNQ2 antibody IHC-P image
Immunohistochemistry: Human breast cancer stained with ARG45617 anti-KCNQ2 antibody at 2 μg/ml dilution.
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ARG45617 anti-KCNQ2 antibody WB image
Western blot: HEK293 stained with ARG45617 anti-KCNQ2 antibody at 0.5 μg/ml dilution.
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ARG45617 anti-KCNQ2 antibody FACS image
Flow Cytometry: 293T stained with ARG45617 anti-KCNQ2 antibody at 1 µg/10^6 cells dilution.
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ARG45617 anti-KCNQ2 antibody WB image
Western blot: Rat brain stained with ARG45617 anti-KCNQ2 antibody at 0.5 μg/ml dilution.
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ARG45617 anti-KCNQ2 antibody WB image
Western blot: Mouse brain stained with ARG45617 anti-KCNQ2 antibody at 0.5 μg/ml dilution.
