ARG45650
anti-KHSRP antibody
anti-KHSRP antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KHSRP |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KHSRP |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human KHSRP. |
| Conjugation | Un-conjugated |
| Alternate Names | KHSRP; KH-Type Splicing Regulatory Protein; FUBP2; KSRP; FBP2; Far Upstream Element-Binding Protein 2; FUSE-Binding Protein 2; P75; Epididymis Secretory Sperm Binding Protein; KH Type-Splicing Regulatory Protein; FUSE Binding Protein 2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 85 - 90 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q92945 Human Far upstream element-binding protein 2 Swiss-port # Q99PF5 Rat Far upstream element-binding protein 2 |
|---|---|
| Gene Symbol | KHSRP |
| Gene Full Name | KH-Type Splicing Regulatory Protein |
| Background | The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010] |
| Function | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 73 kDa |
| PTM | Acetylation; Isopeptide bond; Methylation; Phosphoprotein; Ubl conjugation. [UniProt] |
Images (8) Click the Picture to Zoom In
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ARG45650 anti-KHSRP antibody IHC-P image
Immunohistochemistry: Human gallbladder adenocarcinoma stained with ARG45650 anti-KHSRP antibody at 2 μg/ml dilution.
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ARG45650 anti-KHSRP antibody ICC/IF image
Immunofluorescence: CACO-2 stained with ARG45650 anti-KHSRP antibody at 5 μg/ml dilution.
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ARG45650 anti-KHSRP antibody WB image
Western blot: HEK293 and Hela stained with ARG45650 anti-KHSRP antibody at 0.5 μg/ml dilution.
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ARG45650 anti-KHSRP antibody FACS image
Flow Cytometry: K562 stained with ARG45650 anti-KHSRP antibody at 1 µg/10^6 cells dilution.
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ARG45650 anti-KHSRP antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG45650 anti-KHSRP antibody at 2 μg/ml dilution.
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ARG45650 anti-KHSRP antibody WB image
Western blot: Rat brain stained with ARG45650 anti-KHSRP antibody at 0.5 μg/ml dilution.
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ARG45650 anti-KHSRP antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG45650 anti-KHSRP antibody at 2 μg/ml dilution.
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ARG45650 anti-KHSRP antibody WB image
Western blot: Mouse brain stained with ARG45650 anti-KHSRP antibody at 0.5 μg/ml dilution.
