ARG47125
anti-KIF7 antibody
anti-KIF7 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Mouse
Overview
| Product Description | Mouse Monoclonal antibody recognizes KIF7 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | ICC/IF, IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | KIF7 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of human KIF7. |
| Conjugation | Un-conjugated |
| Alternate Names | KIF7; Kinesin-like protein KIF7 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS, 0.09% Sodium azide, 50% Glycerol and 0.5% BSA |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | KIF7 |
|---|---|
| Gene Full Name | kinesin family member 7 |
| Background | This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011] |
| Function | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. [UniProt] |
| Cellular Localization | Cell projection; Cytoplasm; Cytoskeleton. [UniProt] |
| Calculated MW | 151 kDa |
| PTM | Phosphoprotein; Ubl conjugation. [UniProt] |
