ARG21413

anti-KIR3DL1 antibody [DX9] (APC)

anti-KIR3DL1 antibody [DX9] (APC) for Flow cytometry,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF,Blocking and Human,Baboon

Overview

Product Description APC-conjugated Mouse Monoclonal antibody [DX9] recognizes KIR3DL1
Tested Reactivity Hu, Bb
Tested Application BL, FACS, ICC/IF, IHC-Fr, IHC-P
Specificity Human/Baboon CD158e1
Host Mouse
Clonality Monoclonal
Clone DX9
Isotype IgG1, kappa
Target Name KIR3DL1
Antigen Species Human
Immunogen Human NK clone VL186-1 (CD3-, CD16+, CD56+)
Conjugation APC
Full Name killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
Alternate Names NKAT3; CD158E1; NKAT-3; Natural killer-associated transcript 3; Killer cell immunoglobulin-like receptor 3DL1; KIR; p70 NK receptor CL-2/CL-11; CD158 antigen-like family member E; NKB1B; CD antigen CD158e; p70 natural killer cell receptor clones CL-2/CL-11; NKB1; MHC class I NK cell receptor; KIR3DL2; HLA-BW4-specific inhibitory NK cell receptor; KIR3DL1/S1

Application Instructions

Application Suggestion
Tested Application Dilution
BLAssay-dependent
FACS10 µl/10^6 cells
ICC/IFAssay-dependent
IHC-FrAssay-dependent
IHC-PAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 49 kDa

Properties

Form Liquid
Buffer PBS, Sodium azide and a stabilizing agent
Preservative Sodium azide
Storage instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 3811 Human KIR3DL1

Swiss-port # P43629 Human Killer cell immunoglobulin-like receptor 3DL1

Gene Symbol KIR3DL1
Gene Full Name killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
Background Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Function Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. [UniProt]