ARG54796

anti-KMT1B / SUV39H2 antibody

anti-KMT1B / SUV39H2 antibody for Western blot and Human,Mouse

Gene Regulation antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes KMT1B / SUV39H2
Tested Reactivity Hu, Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name KMT1B / SUV39H2
Antigen Species Human
Immunogen Recombinant protein of Human SUV39H2 (NP_001180353.1)
Conjugation Un-conjugated
Alternate Names H3-K9-HMTase 2; KMT1B; Lysine N-methyltransferase 1B; Histone-lysine N-methyltransferase SUV39H2; EC 2.1.1.43; Su; Histone H3-K9 methyltransferase 2; var; Suppressor of variegation 3-9 homolog 2

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse heart and SW620

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 64707 Mouse SUV39H2

GeneID: 79723 Human SUV39H2

Swiss-port # Q9EQQ0 Mouse Histone-lysine N-methyltransferase SUV39H2

Swiss-port # Q9H5I1 Human Histone-lysine N-methyltransferase SUV39H2

Gene Symbol SUV39H2
Gene Full Name suppressor of variegation 3-9 homolog 2 (Drosophila)
Function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. [UniProt]
Research Area Gene Regulation antibody
Calculated MW 47 kDa

Images (1) Click the Picture to Zoom In

  • ARG54796 anti-KMT1B / SUV39H2 antibody WB image

    Western blot: Mouse heart and SW620 cell lysates stained with ARG54796 anti-KMT1B / SUV39H2 antibody.