ARG46253
anti-LEMD3 / MAN1 antibody
anti-LEMD3 / MAN1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes LEMD3 / MAN1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | LEMD3 / MAN1 |
| Antigen Species | Human |
| Immunogen | A 18 amino acid synthetic peptide within the last 50 amino acids of human LEMD3 / MAN1. |
| Conjugation | Un-conjugated |
| Alternate Names | LEMD3; LEMD3; LEM Domain Containing 3; MAN1; Inner Nuclear Membrane Protein Man1; LEM Domain-Containing Protein 3; MAN Antigen 1; Integral Inner Nuclear Membrane Protein; LEMD3/MKX Fusion |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9WU40 Mouse Inner nuclear membrane protein Man1 Swiss-port # Q9Y2U8 Human Inner nuclear membrane protein Man1 |
|---|---|
| Gene Symbol | LEMD3 |
| Gene Full Name | LEM domain containing 3 |
| Background | This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. |
| Function | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest |
| Cellular Localization | Membrane, Nucleus |
| Calculated MW | 100 kDa |
| PTM | Acetylation, Phosphoprotein |
Images (2) Click the Picture to Zoom In
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ARG46253 anti-LEMD3 / MAN1 antibody IHC-P image
Immunohistochemistry: Human colon stained with ARG46253 anti-LEMD3 / MAN1 antibody.
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ARG46253 anti-LEMD3 / MAN1 antibody WB image
Western blot: Human colon stained with ARG46253 anti-LEMD3 / MAN1 antibody.
