ARG46259
anti-LNPEP antibody
anti-LNPEP antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes LNPEP |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | LNPEP |
| Antigen Species | Human |
| Immunogen | A 15 amino acid synthetic peptide within aa. 900 - 950 of human LNPEP. |
| Conjugation | Un-conjugated |
| Alternate Names | leucyl/cystinyl aminopeptidase; LNPEP; CAP; IRAP; PLAP; P-LAP; OTASE; Leucyl-cystinyl aminopeptidase; Insulin-regulated membrane aminopeptidase; Cystinyl aminopeptidase |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -309°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | LNPEP |
| Gene Full Name | leucyl/cystinyl aminopeptidase |
| Background | This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| Function | Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. [UniProt] |
| Cellular Localization | Cell membrane. [UniProt] |
| Calculated MW | 117 kDa |
| PTM | Phosphoprotein; Glycoprotein; Acetylation. [UniProt] |
