ARG46963
anti-LSECtin antibody
anti-LSECtin antibody for IHC-Formalin-fixed paraffin-embedded sections,ELISA and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes LSECtin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | LSECtin |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human LSECtin. |
| Conjugation | Un-conjugated |
| Alternate Names | CLEC4G; C-type lectin domain family 4 member G; Liver and lymph node sinusoidal endothelial cell C-type lectin; LSECtin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A |
| Buffer | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6UXB4 Human C-type lectin domain family 4 member G |
|---|---|
| Gene Symbol | CLEC4G |
| Gene Full Name | C-type lectin domain family 4 member G |
| Background | This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020] |
| Function | Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro. [UniProt] |
| Cellular Localization | Cell membrane; Membrane. [UniProt] |
| Calculated MW | 33 kDa |
| PTM | Disulfide bond; Glycoprotein; Phosphoprotein. [UniProt] |
