ARG46278
anti-MACC1 antibody
anti-MACC1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MACC1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MACC1 |
| Antigen Species | Human |
| Immunogen | A 17 amino acid synthetic peptide within aa. 430 - 480 of human MACC1. |
| Conjugation | Un-conjugated |
| Alternate Names | MACC1; SH3BP4L; 7A5; SH3 domain-containing protein 7a5; Metastasis-associated in colon cancer protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 90 kDa |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6ZN28 Human Metastasis-associated in colon cancer protein 1 |
|---|---|
| Gene Symbol | MACC1 |
| Gene Full Name | metastasis associated in colon cancer 1 |
| Background | MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009] |
| Function | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. [UniProt] |
| Cellular Localization | Cytoplasm, Nucleus |
| Calculated MW | 94 kDa |
Images (3) Click the Picture to Zoom In
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ARG46278 anti-MACC1 antibody IHC-P image
Immunohistochemistry: Human liver stained with ARG46278 anti-MACC1 antibody.
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ARG46278 anti-MACC1 antibody ICC/IF image
Immunofluorescence: Human liver stained with ARG46278 anti-MACC1 antibody.
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ARG46278 anti-MACC1 antibody WB image
Western blot: Mouse liver stained with ARG46278 anti-MACC1 antibody.
