ARG46279
anti-MAEL antibody
anti-MAEL antibody for Western blot,ICC/IF and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MAEL |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MAEL |
| Antigen Species | Human |
| Immunogen | A 16 amino acid synthetic peptide within aa. 30 - 80 of human MAEL. |
| Conjugation | Un-conjugated |
| Alternate Names | MAEL; MAEL; Maelstrom Spermatogenic Transposon Silencer; SPATA35; CT128; Spermatogenesis Associated 35; Cancer/Testis Antigen 128; Protein Maelstrom Homolog; FLJ14904; Testicular Tissue Protein Li 116; Maelstrom Homolog (Drosophila); Maelstrom Homolog |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MAEL |
| Gene Full Name | Maelstrom Spermatogenic Transposon Silencer |
| Background | Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in gamete generation; negative regulation of macromolecule metabolic process; and piRNA metabolic process. Predicted to act upstream of or within several processes, including homologous chromosome pairing at meiosis; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of macromolecule metabolic process. Predicted to be located in piP-body. Predicted to be active in P granule and nucleus. |
| Function | Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. |
| Cellular Localization | Cytoplasm, Nucleus |
| Calculated MW | 49 kDa |
Images (2) Click the Picture to Zoom In
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ARG46279 anti-MAEL antibody ICC/IF image
Immunofluorescence: HeLa stained with ARG46279 anti-MAEL antibody.
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ARG46279 anti-MAEL antibody WB image
Western blot: HeLa stained with ARG46279 anti-MAEL antibody.
