ARG46282
anti-MARCHF8 antibody
anti-MARCHF8 antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MARCHF8 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MARCHF8 |
| Antigen Species | Human |
| Immunogen | A 17 amino acid synthetic peptide within the last 50 amino acids of human MARCHF8. |
| Conjugation | Un-conjugated |
| Alternate Names | membrane-associated ring finger (C3HC4) 8; MARCH8; MIR; c-MIR; RNF178; MARCH-VIII; MIR; E3 ubiquitin-protein ligase MARCH8; Cellular modulator of immune recognition |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -332°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q5T0T0 Human E3 ubiquitin-protein ligase MARCH8 Swiss-port # Q9DBD2 Mouse E3 ubiquitin-protein ligase MARCH8 |
|---|---|
| Gene Symbol | MARCH8 |
| Gene Full Name | membrane-associated ring finger (C3HC4) 8 |
| Background | MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010] |
| Function | E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity. [UniProt] |
| Cellular Localization | Cytoplasm; Endosome; Endoplasmic reticulum membrane; Lysosome membrane; Cytoplasmic vesicle; Cytoplasmic vesicle ; Golgi apparatus. [UniProt] |
| Calculated MW | 33 kDa |
| PTM | Phosphoprotein; Ubl conjugation. [UniProt] |
