ARG67351
anti-MDR1 / P Glycoprotein 1 antibody
anti-MDR1 / P Glycoprotein 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Dog,Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MDR1 / P Glycoprotein 1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Dog |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MDR1 / P Glycoprotein 1 |
| Antigen Species | Human |
| Immunogen | MDR1 / P Glycoprotein 1KLH-conjugated synthetic peptide encompassing a sequence within the center region of human |
| Conjugation | Un-conjugated |
| Alternate Names | PGY1; ABC20; P-GP; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; CD antigen CD243; GP170; CLCS; CD243; MDR1; EC 3.6.3.44; P-glycoprotein 1 |
Application Instructions
| Application Suggestion |
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| Observed Size | 180 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen |
| Buffer | 0.42% Potassium phosphate, 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 30% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ABCB1 |
| Gene Full Name | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008] |
| Function | Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. [UniProt] |
| Calculated MW | 141 kDa |
Images (2) Click the Picture to Zoom In
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ARG67351 anti-MDR1 / P Glycoprotein 1 antibody IHC-P image
Immunohistochemistry: Human brain stained with ARG67351 anti-MDR1 / P Glycoprotein 1 antibody.
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ARG67351 anti-MDR1 / P Glycoprotein 1 antibody WB image
Western blot: C6, DLD and BV2 stained with ARG67351 anti-MDR1 / P Glycoprotein 1 antibody.
