anti-MMP3 antibody

anti-MMP3 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse

Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody
publication_link Publication2


Product Description

Rabbit Polyclonal antibody recognizes MMP3

Tested Reactivity Hu, Ms
Tested Application ICC/IF, IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name MMP3
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 30-59 (N-terminus) of Human MMP3.
Conjugation Un-conjugated
Alternate Names Transin-1; CHDS6; EC; SL-1; STMY1; Matrix metalloproteinase-3; STR1; STMY; MMP-3; Stromelysin-1

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:10 - 1:50
IHC-P1:10 - 1:50
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 17392 Mouse MMP3

GeneID: 4314 Human MMP3

Swiss-port # P08254 Human Stromelysin-1

Swiss-port # P28862 Mouse Stromelysin-1

Gene Symbol MMP3
Gene Full Name matrix metallopeptidase 3
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Function Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. [UniProt]
Cellular Localization Secreted, extracellular space, extracellular matrix
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody
Calculated MW 54 kDa

Images (3) Click the Picture to Zoom In

  • ARG55262 anti-MMP3 antibody WB image

    Western blot: 30 µg of MCF7, U2OS, U87-MG, 293T, MEF and NIH3T3 cell lysates stained with ARG55262 anti-MMP3 antibody at 1:500 dilution.

  • ARG55262 anti-MMP3 antibody ICC/IF image

    Immunofluorescence: NCI-H460 cells stained with ARG55262 anti-MMP3 antibody (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI (blue) for nuclear staining.

  • ARG55262 anti-MMP3 antibody IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human tonsil tissue stained with ARG55262 anti-MMP3 antibody.

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Sample:Mouse lung

Sample Loading Amount:30 µg

Primary Antibody Dilution Factor:1:500

Primary Antibody Incubation Time:overnight

Primary Antibody Incubation Temperature:4 ºC

Specific References

Characteristics of Ang-(1-7)/Mas-Mediated Amelioration of Joint Inflammation and Cardiac Complications in Mice With Collagen-Induced Arthritis.

IHC-P / Mouse

Zhongjie Wang et al.
Front Immunol.,  (2021)




Septin 9 isoforms promote tumorigenesis in mammary epithelial cells by increasing migration and ECM degradation through metalloproteinase secretion at focal adhesions.

WB, ICC/IF / Human

Marcus Jenna et al.
Oncogene.,  (2019)