ARG10402

anti-MPO / Myeloperoxidase antibody [4A4]

anti-MPO / Myeloperoxidase antibody [4A4] for ELISA,Western blot and Human

Cancer antibody; Cell Biology and Cellular Response antibody; Immune System antibody; Metabolism antibody

Overview

Product Description Mouse Monoclonal antibody [4A4] recognizes MPO / Myeloperoxidase
Tested Reactivity Hu
Tested Application ELISA, WB
Host Mouse
Clonality Monoclonal
Clone 4A4
Isotype IgG2b
Target Name MPO / Myeloperoxidase
Antigen Species Human
Immunogen purified human MPO
Conjugation Un-conjugated
Full Name myeloperoxidase
Alternate Names MPO; Myeloperoxidase; EC 1.11.2.2

Application Instructions

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein A affinity purified.
Buffer PBS (pH 7.4) and 0.1% Sodium azide
Preservative 0.1% Sodium azide
Concentration 1.0-2.0 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 4353 Human MPO

Swiss-port # P05164 Human Myeloperoxidase

Gene Symbol MPO
Gene Full Name myeloperoxidase
Background Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Function Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. [UniProt]
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Immune System antibody; Metabolism antibody

Clone References

In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis.

IHC / Human

Appel H et al.
Arthritis Rheum.,  (2013)

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Ligation of the jugular veins does not result in brain inflammation or demyelination in mice.

IHC / Mouse

Atkinson W et al.
PLoS One.,  (2012)

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Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.

IHC / Rat

Kleijn A et al.
Clin Cancer Res.,  (2011)

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Protective role of simvastatin on lung damage caused by burn and cotton smoke inhalation in rats.

IHC / Rat

Belli S et al.
J Surg Res.,  (2011)

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Curcumin prevents and reverses murine cardiac hypertrophy.

Li HL et al.
J Clin Invest.,  (2008)

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