anti-MUC2 / Mucin 2 antibody [SQab21246]
anti-MUC2 / Mucin 2 antibody [SQab21246] for IHC-Formalin-fixed paraffin-embedded sections and Human
|Product Description||Mouse Monoclonal antibody [SQab21246] recognizes MUC2 / Mucin 2|
|Target Name||MUC2 / Mucin 2|
|Immunogen||A 29-amino acid synthetic peptide containing one repeat unit of 23 amino acids and part of the next repeat of four amino acids in the VNTR (variable number of tandem repeats).|
|Alternate Names||MUC-2; MLP; Intestinal mucin-2; SMUC; Mucin-2|
|Application Note||IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|Purification||Purification with Protein G.|
|Buffer||PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.|
|Preservative||0.01% Sodium azide|
|Stabilizer||40% Glycerol and 0.05% BSA|
|Storage Instruction||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Gene Full Name||mucin 2, oligomeric mucus/gel-forming|
|Function||Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. [UniProt]|
|Calculated MW||540 kDa|
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway. [UniProt]
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ARG66874 anti-MUC2 / Mucin 2 antibody [SQab21246] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human appendix tissue. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). The tissue section was stained with ARG66874 anti-MUC2 / Mucin 2 antibody [SQab21246] for 30 min at RT.