anti-Mucin 5AC antibody [45M1]

anti-Mucin 5AC antibody [45M1] for IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat


Product Description Mouse Monoclonal antibody [45M1] recognizes Mucin 5AC
Tested Reactivity Hu, Ms, Rat
Species Does Not React With Cow
Tested Application IHC-P
Host Mouse
Clonality Monoclonal
Clone 45M1
Isotype IgG1, kappa
Target Name Mucin 5AC
Antigen Species Human
Immunogen Mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient.
Conjugation Un-conjugated
Alternate Names leB; Major airway glycoprotein; Lewis B blood group antigen; Tracheobronchial mucin; mucin; Mucin-5AC; LeB; MUC5; TBM; Gastric mucin; MUC-5AC; Mucin-5 subtype AC, tracheobronchial

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1 - 2 µg/ml
Application Note IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Citrate buffer (pH 6.0) for 10-20 min, followed by cooling at RT for 20 min.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Purification with Protein G.
Buffer PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA
Preservative 0.05% Sodium azide
Stabilizer 0.1 mg/ml BSA
Concentration 0.2 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 4586 Human MUC5AC

Gene Symbol MUC5AC
Gene Full Name mucin 5AC, oligomeric mucus/gel-forming
Function Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system. [UniProt]
Cellular Localization Cytoplasmic
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Calculated MW 586 kDa
PTM C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.

Images (3) Click the Picture to Zoom In

  • ARG55970 anti-Mucin 5AC antibody [45M1] IHC-P image

    Immunohistochemistry: Human stomach stained with ARG55970 anti-Mucin 5AC antibody [45M1].

  • ARG55970 anti-Mucin 5AC antibody [45M1] IHC-P image

    Immunohistochemistry: Human gastric carcinoma stained with ARG55970 anti-Mucin 5AC antibody [45M1].

  • ARG55970 anti-Mucin 5AC antibody [45M1] IHC-P image

    Immunohistochemistry: Rat stomach stained with ARG55970 anti-Mucin 5AC antibody [45M1].