Overview

Product Description	Rabbit Polyclonal antibody recognizes NLRP5
Tested Reactivity	Hu, Ms, Rat
Tested Application	IHC-P, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	NLRP5
Antigen Species	Human
Immunogen	A 14 amino acid synthetic peptide within the last 50 amino acids of human NLRP5.
Conjugation	Un-conjugated
Alternate Names	NLRP5; NLR Family Pyrin Domain Containing 5; MATER; Maternal Antigen That Embryos Require; CLR19.8; PYPAF8; PAN11; NALP5; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 5; NACHT, Leucine Rich Repeat And PYD Containing 5; NACHT, LRR And PYD Domains-Containing Protein 5; Mater Protein Homolog; OZEMA19

Application Instructions

Application Suggestion	Tested Application Dilution IHC-P Assay-dependent WB Assay-dependent
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Purification	Affinity chromatography purified
Buffer	PBS and 0.02% Sodium azide.
Preservative	0.02% Sodium azide
Concentration	1 mg/ml
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 126206 Human NLRP5 GeneID: 23968 Mouse NLRP5 Swiss-port # P59047 Human NACHT, LRR and PYD domains-containing protein 5 Swiss-port # Q9R1M5 Mouse NACHT, LRR and PYD domains-containing protein 5
Gene Symbol	NLRP5
Gene Full Name	NLR Family Pyrin Domain Containing 5
Background	The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis.
Function	As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics.
Cellular Localization	Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Mitochondrion, Nucleus
Calculated MW	134 kDa

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