Overview

Product Description	Rabbit Polyclonal antibody recognizes NLRP6
Tested Reactivity	Hu
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	NLRP6
Antigen Species	Human
Immunogen	A 16 amino acid synthetic peptide within aa. 150 - 200 of human NLRP6.
Conjugation	Un-conjugated
Alternate Names	NLRP6; PAN3; PYPAF5; NACHT, LRR and PYD domains-containing protein 6; CLR11.4; AVR; PYRIN-containing APAF1-like protein 5; NAVR; Angiotensin II/vasopressin receptor; NALP6; NAVR/AVR

Application Instructions

Application Suggestion	Tested Application Dilution WB Assay-dependent
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Purification	Affinity chromatography purified
Buffer	PBS and 0.02% Sodium azide.
Preservative	0.02% Sodium azide
Concentration	1 mg/ml
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 171389 Human NLRP6 Swiss-port # P59044 Human NACHT, LRR and PYD domains-containing protein 6
Gene Symbol	NLRP6
Gene Full Name	NLR family, pyrin domain containing 6
Background	The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Function	May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation (By similarity). [UniProt]
Cellular Localization	Cytoplasm. Inflammasome. Cell membrane. Nucleus membrane. [UniProt]
Calculated MW	99 kDa

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