ARG10604

anti-NMDAR2B antibody

anti-NMDAR2B antibody for Western blot and Human,Mouse,Rat

Overview

Product Description

Rabbit Polyclonal antibody recognizes NMDAR2B

Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Target Name NMDAR2B
Antigen Species Human
Immunogen Synthetic peptide around aa. 1307-1320 of NMDAR2B protein (100% homologous in Human, Mouse and Rat). (FVDLQKEEAALAPR)
Conjugation Un-conjugated
Full Name glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Alternate Names MRD6; EIEE27; NR2B; hNR3; GluN2B; NR3; N-methyl D-aspartate receptor subtype 2B; Glutamate receptor ionotropic, NMDA 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl-D-aspartate receptor subunit 3; NMDAR2B

Application Instructions

Application Suggestion
Tested Application Dilution
WB0.5 - 1 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 166 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.025% Sodium azide and 2.5% BSA.
Preservative 0.025% Sodium azide
Stabilizer 2.5% BSA
Concentration 0.5 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 14812 Mouse GRIN2B

GeneID: 24410 Rat GRIN2B

GeneID: 2904 Human GRIN2B

Gene Symbol GRIN2B
Gene Full Name glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Background N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
Function NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). [UniProt]
PTM Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity.

Images (1) Click the Picture to Zoom In

  • ARG10604 anti-NMDAR2B antibody WB image

    Western blot: 1) Rat brain, 2) Mouse brain, and 3) Human U87 cell lysate stained with ARG10604 anti-NMDAR2B antibody.