ARG46337
anti-NOTUM antibody
anti-NOTUM antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NOTUM |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NOTUM |
| Antigen Species | Human |
| Immunogen | A 19 amino acid synthetic peptide within the last 50 amino acids of human NOTUM. |
| Conjugation | Un-conjugated |
| Alternate Names | notum pectinacetylesterase homolog (Drosophila); NOTUM; Protein notum homolog |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -387°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6P988 Human Palmitoleoyl-protein carboxylesterase NOTUM Swiss-port # Q8R116 Mouse Palmitoleoyl-protein carboxylesterase NOTUM |
|---|---|
| Gene Symbol | NOTUM |
| Gene Full Name | notum pectinacetylesterase homolog (Drosophila) |
| Background | Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Jul 2025] |
| Function | Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 56 kDa |
| PTM | Phosphoprotein; Glycoprotein. [UniProt] |
