ARG10407

anti-NT-proBNP antibody [13G12]

anti-NT-proBNP antibody [13G12] for ELISA,Western blot and Human

Overview

Product Description Mouse Monoclonal antibody [13G12] recognizes NT-proBNP
Tested Reactivity Hu
Tested Application ELISA, WB
Host Mouse
Clonality Monoclonal
Clone 13G12
Isotype IgG2a
Target Name NT-proBNP
Antigen Species Human
Conjugation Un-conjugated
Full Name N-terminal prohormone of brain natriuretic peptide
Alternate Names Natriuretic peptide B; BNP; BNP-32; Gamma-brain natriuretic peptide; Ventricular natriuretic peptide; brain natriuretic peptide; B-type natriuretic peptide; BNPT

Application Instructions

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein A purified
Purification Note Purified from cell culture supernatant.
Concentration 1.0-2.0 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 4879 Human NPPB

Swiss-port # P16860 Human Natriuretic peptides B

Gene Symbol NPPB
Background This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
Function May affect cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32 (PubMed:17372040). [UniProt]
Cellular Localization Secreted. [UniProt]
Calculated MW 15 kDa
PTM The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro). [UniProt]