ARG45511
anti-NXN / NRX antibody
anti-NXN / NRX antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NXN / NRX |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NXN / NRX |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human NXN / NRX. |
| Conjugation | Un-conjugated |
| Alternate Names | NXN; Nucleoredoxin; NRX; EC 1.8.1.8 47; FLJ12614; Nucleoredoxin 1; TRG-4; RRS2 |
Application Instructions
| Application Suggestion |
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 48 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | NXN |
| Gene Full Name | Nucleoredoxin |
| Background | This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015] |
| Function | Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 48 kDa |
| PTM | Acetylation. [UniProt] |
Images (4) Click the Picture to Zoom In
-
ARG45511 anti-NXN / NRX antibody IHC-P image
Immunohistochemistry: Human placenta stained with ARG45511 anti-NXN / NRX antibody at 2 μg/ml dilution.
-
ARG45511 anti-NXN / NRX antibody ICC/IF image
Immunofluorescence: Caco-2 stained with ARG45511 anti-NXN / NRX antibody at 5 μg/ml dilution.
-
ARG45511 anti-NXN / NRX antibody WB image
Western blot: Caco-2 stained with ARG45511 anti-NXN / NRX antibody at 0.5 μg/ml dilution.
-
ARG45511 anti-NXN / NRX antibody FACS image
Flow Cytometry: SiHa stained with ARG45511 anti-NXN / NRX antibody at 1 µg/10^6 cells dilution.
