ARG67312
anti-Nav1.6 / SCN8A antibody
anti-Nav1.6 / SCN8A antibody for ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Nav1.6 / SCN8A |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Nav1.6 / SCN8A |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide within the center region of Human Nav1.6 / SCN8A. |
| Conjugation | Un-conjugated |
| Alternate Names | Nav1.6; SCN8A; Sodium Voltage-Gated Channel Alpha Subunit ; MED; Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen |
| Buffer | 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 30% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SCN8A |
| Gene Full Name | Sodium Voltage-Gated Channel Alpha Subunit |
| Background | This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| Function | Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. [UniProt] |
| Cellular Localization | Cell junction; Cell membrane; Cell projection; Cytoplasmic vesicle; Membrane. [UniProt] |
| Calculated MW | 225 kDa |
| PTM | Disulfide bond; Glycoprotein; Phosphoprotein; Ubl conjugation. [UniProt] |
Images (4) Click the Picture to Zoom In
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ARG67312 anti-Nav1.6 / SCN8A antibody ICC/IF image
Immunofluorescence: Hela stained with ARG67312 anti-Nav1.6 / SCN8A antibody.
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ARG67312 anti-Nav1.6 / SCN8A antibody WB image
Western blot: MCF7 stained with ARG67312 anti-Nav1.6 / SCN8A antibody.
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ARG67312 anti-Nav1.6 / SCN8A antibody WB image
Western blot: H9C2 stained with ARG67312 anti-Nav1.6 / SCN8A antibody.
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ARG67312 anti-Nav1.6 / SCN8A antibody WB image
Western blot: Raw264.7 stained with ARG67312 anti-Nav1.6 / SCN8A antibody.
