ARG46325
anti-Neurotrypsin antibody
anti-Neurotrypsin antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Neurotrypsin |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Neurotrypsin |
| Antigen Species | Human |
| Immunogen | A 23 amino acid synthetic peptide within aa. 110 - 160 of human Neurotrypsin. |
| Conjugation | Un-conjugated |
| Alternate Names | PRSS12; protease, serine, 12 (neurotrypsin, motopsin); Neurotrypsin; MRT1; BSSP3; BSSP-3; Neurotrypsin; Leydin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 96 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -375°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PRSS12 |
| Gene Full Name | protease, serine, 12 (neurotrypsin, motopsin) |
| Background | This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017] |
| Function | Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. [UniProt] |
| Cellular Localization | Secreted.. [UniProt] |
| Calculated MW | 96 kDa |
| PTM | Disulfide bond; Glycoprotein. [UniProt] |
